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"Charge-shifting" polyacrylates

"Charge-shifting" polyacrylates

RAFT-polymerized cationic polyacrylates with tunable compositions, molar masses, and low dispersities spontaneously associate DNA to form polyplexes at a low N/P ratio. After polyplexe incubation, the “charge-shifting” behavior of polyacrylates leads to DNA release without any trigger.

Researchers

  • Sagrario Pascual
  • Sandie Piogé
  • Véronique Montembault
  • Laurent Fontaine

Related papers

  • T. Ho, S. Pascual, V. Montembault, N. Casse, L. Fontaine, Polym. Chem. 2014, 5, 5542
  • T. Ho, M. Le Bohec, J. Frémaux, S. Piogé, N. Casse, L. Fontaine, S. Pascual, Macromol. Rapid Commun. 2017, 38, Article Number 1600641
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