Boeda, Fabien

Parcours

• Sept 2009

Maître de conférences Université du Maine - IMMM 

• Oct. 2008 – Août 2009

Position de recherche post-doctorale dans le groupe du Professeur C. Kouklovsky à l’Institut de Chimie Moléculaire et des Matériaux d’Orsay (ICMMO) – Université Paris Sud XI – Orsay – France

Etude de réactions d’hydroaminations énantiosélectives catalysées par des complexes de lanthanides. Application à la synthèse de nouveaux alcaloïdes.

• Janv. 2007 – Sept. 2008

Position de recherche post-doctorale dans le groupe du Professeur S. P. Nolan à l’Institute of Chemical Research of Catalonia (ICIQ) – Tarragona – Espagne

Synthèse de complexes de ruthénium. Applications en métathèse

• Oct. 2003 – Nov. 2006

Thèse de doctorat réalisée au laboratoire Sciences Chimiques de Rennes (Équipe Synthèse Organique Systèmes Organisés – CNRS UMR 6226 – École Nationale Supérieure de Chimie de Rennes) et supervisée par les Drs. Paul MOSSET et Christophe CRÉVISY

Synthèse de ligands phosphorés. Applications en catalyse asymétrique

 Activités d'Enseignement

Université du Maine - UFR Sciences et Techniques

Chimie Organique et Organométallique, Biochimie, Chimie analytique (L1, L3, M1, M2).

Activités de Recherche

Synthèse, caractérisation et utilisation de nouveaux réactifs stanniques supportés sur liquide ionique - Applications en catalyse organométallique.

Synthèse de Carbènes N-Hétérocycliques. Applications en catalyse énantiosélective.

Publications

26. "Zinc-mediated double addition on functionnalized nitriles"  J. Caillé, M. Pantin, F. Boeda, M. S. M. Pearson-Long, P. Bertus, Synthesis 2019 , 51, 1329-1341.

25. "Synthesis and biological evaluation of 3-cyano-4H-chromene derivatives bearing carbamate functionality", F. Boukattaya, A. Daoud, F. Boeda, M. S. M. Pearson-Long, N. Gharsallah, A. Kadri, P. Bertus, H. Ammar, Med. Chem. 2019, 15, 1-8.

24. "Asymmetric Titanium-Catalyzed Cyclopropanation of Nitriles with Grignard Reagents", J. Caillé, P. Setzer, F. Boeda, M. S. M. Pearson-Long, P. Bertus, SynOpen 2018, 02(01), 41-49.

23. "Successive addition of two different Grignard reagents to nitriles: access to α,α-disubstituted propargylamine derivatives", J. Caillé, F. Boukattaya, F. Boeda, M. S. M. Pearson-Long, H. Ammar, P. Bertus, Org. Biomol. Chem. 2018, 16, 1519-1526.

22. "Double Addition of Organometallics to Nitriles: Toward an Access to Tertiary Carbinamine", M. S. M. Pearson-Long, F. Boeda, P. Bertus, Adv. Synth. Catal. 2017, 359, 179-201.

21. "Ionic Liquid supported organotin reagents to prepare molecular imaging and therapy agents", H. Rajerison, D. Faye, A. Roumesy, N. Louaisil, F. Boeda, A. Faivre-Chauvet, J-F. Gestin, S. Legoupy, Org. Biomol. Chem. 2016, 14, 2121-2126.

20. "A short Access to α,α-Disubstituted α-Amino Acids from Acyl Cyanohydrins" F. Boukattaya, J. Caillé, H. Ammar, F. Rouzier, F. Boeda, M. S. M. Pearson-Long, P. Bertus, Synthesis 2016 , 48, 906-916.

19."A Stereoselective access to a ferrocene-based planar chiral triazolium salt" G. Forcher, A. Silvanus, P. de Frémont, B. Jacques,  M. S. M. Pearson-Long, F. Boeda,  P. Bertus, J. Organomet. Chem. 2015, 797, 1-7.

18."Titanium-mediated cyclopropanation of nitriles with unsaturated Grignard reagents : Application to the synthesis of constrained lysine derivatives" G. Forcher, N. Clousier, A. Beauseigneur, P. Setzer, F. Boeda, M. S. M. Pearson-Long, P. Karoyan, J. Szymoniak, P. Bertus, Synthesis 2015, 47, 992-1006.

17."Titanium-mediated addition of Grignard reagents to acyl cyanohydrins: aminocyclopropane versus 1,4-diketone formation" P. Setzer, G. Forcher, F. Boeda, M. S. M. Pearson-Long, P. Bertus, Eur. J. Org. Chem. 2014, 1, 171-180.

16."Solvent free hydrostannation and Stille reactions using ionic liquid supported organotin reagents" D. Faye, M. Vybornyi, F. Boeda, S. Legoupy, Tetrahedron 2013, 69, 5421-5425.

15. “Enantioselective Intramolecular Hydroamination of Secondary Amines Catalyzed by Easily Accessible Ate and Neutral Rare-Earth Complexes” C. Queffelec, F. Boeda, A. Pouilhès, A. Meddour, C. Kouklovsky, J. Hannedouche, J. Collin, E. Schulz, Chem. Cat. Chem. 2011, 3, 122-126.

14. “Ionic Liquid Supported Organotin Reagents. Green Tools for Stille Cross-Coupling Reactions with Brominated Substrates” N. Louaisil, P. D. Pham, F. Boeda, D. Faye, A-S. Castanet, S. Legoupy, Eur. J. Org. Chem. 2011, 143-149.

13. “Palladium [N,N’-bis(2,6-diisopropylphenyl)imidazol-2-ylidene] cinnamylchloride” F. Boeda, S. P. Nolan, Electronic Encyclopedia of Reagents for Organic Synthesis DOI : 10.1002/047084289X.rn00913.

12. “Palladium [N,N’-bis(2,6-diisopropylphenyl)imidazol-2-ylidene] chloroacetylacetonate” F. Boeda, S. P. Nolan, Electronic Encyclopedia of Reagents for Organic Synthesis DOI : 10.1002/047084289X.rn00914.

11. “Towards long-living metathesis catalysts by tuning the N-Heterocyclic Carbene (NHC) Ligand on trifluoroacetamide-activated boomerang Ru-complexes” H. Clavier, F. Caijo, E. Borre, D. Rix, F. Boeda, S. P. Nolan, M. Mauduit, Eur. J. Org. Chem. 2009, 4254-4265.

10. “Ruthenium-indenylidene complexes : scope in cross-metathesis transformations” F. Boeda, X. Bantreil, H. Clavier, S. P. Nolan, Adv. Synth. Catal. 2008, 350, 2959-2966.

9. “Recent advances in ruthenium-indenylidene mediated olefin metathesis” H. Clavier, F. Boeda, S. P. Nolan, Chim. Oggi 2008, 26, 54-56.

8. “N-Heterocyclic carbenes-containing complexes in catalysis” F. Boeda, S. P. Nolan, Annu. Rep. Chem., Sect. B 2008, 104, 184-210.

7. “Ruthenium-indenylidene complexes : powerful tools for metathesis transformations” F. Boeda, H. Clavier, S. P. Nolan, Chem. Commun. 2008, 5, 96-127.

6. “Hybrid bidentate phosphoramidite ligands in asymmetric catalysis” F. Boeda, T. Beneyton, C. Crévisy, Mini-Reviews in Organic Chemistry 2008, 2726-2740.

5. “Aminocarbonyl group containing Hoveyda−Grubbs-type complexes : synthesis and activity in olefin metathesis transformations” D. Rix, F. Caïjo, I. Laurent, F. Boeda, H. Clavier, S. P. Nolan, M. Mauduit, J. Org. Chem. 2008, 73, 4225-4228.

4. “Phosphabicyclononane-containing Ru complexes : efficient pre-catalysts for olefin metathesis reactions” F. Boeda, H. Clavier, M. Jordaan, W. H. Meyer, S. P. Nolan, J. Org. Chem. 2008, 73, 259-263.

3. “Design and synthesis of new bidentate phosphoramidite ligands for enantioselective copper-catalyzed conjugate addition of diethylzinc to enones” F. Boeda, D. Rix, H. Clavier, C. Crévisy, M. Mauduit, Tetrahedron : Asymmetry 2006, 19, 2726-2729.

2. “First rhodium/phosphoramidite complex-catalyzed enantioselective isomerization of allylic alcohols into aldehydes” F. Boeda, P. Mosset, C. Crévisy, Tetrahedron Lett. 2006, 29, 5021-5024.

1. “Efficient synthesis of new nucleoside analogues with a methylenecyclobutane unit” S. Danappe, F. Boeda, C. Alexandre, A. M. Aubertin, N. Bourgougnon, F. Huet, Synth. Commum. 2006, 21, 3225-3239.

Chapitres de livre

2. "Titanium Based Catalysts for Asymmetric Transformations in Sustainable Catalysis: With Non-endangered Metals", P. Bertus, F. Boeda, M. S. M. Pearson-Long, RSC Green Chemistry , Ed. Michael North, 2016, Part 1 (chapter 7),  140-198.

1.“Titanium-Mediated Synthesis of Cyclopropyl Derivatives ” P. Bertus, F. Boeda, M. Pearson-Long, Science of Synthesis Knowledge Updates 2012, 1, 1-50.

Brevets

1."Ionic Liquid supported organotin reagents for the manufacturing of radiopharmaceuticals compounds" S. Legoupy, D. Faye, J.-F. Gestin, H. Rajerison, A. Faivre-Chauvet , F. Boeda,  2014 (EP 14150296.3-1451); 2015 (PCT/EP2015/050180).

2. "Preparation of polyfunctional azlactones, functionalization and use thereof for coupling with biol. molecules, and diagnostic methods" P. Bertus, L. Fontaine, M. Pearson-Long, F. Boeda, J. Caille, V. Gaignet, 2018 (FR 3054546 A1 20180202); 2018 (WO 2018019527 A1 20180201).