Innovative heterofunctional monomers and linkers

Design of innovative hetero-functional monomers (cyclobutene, vinylazlactone, aminoethyl acrylate) as a toolbox for the elaboration of original macromolecular architectures according to controlled/living polymerization processes (RAFT polymerization, NMP, ROMP, ROP) resulting in polyfunctional polymers for potential biomedical applications.

Azlactone-based heterobifunctional linkers that proceed in orthogonal click-like reactions for chemical ligations in biologically relevant medium without releasing any by-product have been successfully synthesized.

Researchers

• Sagrario Pascual
• Sandie Piogé
• Véronique Montembault
• Laurent Fontaine

Related papers

• Fontaine, H. T. Ho, S. Pascual, V. Montembault, PCT WO2014060357; US 20150285811A1; Japanese Patent n° 6262746 (2017)
• T.H. Ho, M.E. Levere, S. Pascual, V. Montembault, N. Casse, A. Caruso, L. Fontaine, Polym. Chem. 2013, 4, 675-685
• Le, G. Morandi, S. Legoupy, S. Pascual, V. Montembault, L. Fontaine, Eur. Polym. J. 2013, 49, 972-983
• T. Ho, S. Pascual, V. Montembault, N. Casse, L. Fontaine, Polym. Chem. 2014, 5, 5542
• Leroux, V. Montembault, S. Pascual, W. Guérin, S. M. Guillaume, L. Fontaine, Polym. Chem. 2014, 5, 3476-3486.
• Delplace, S. Harrisson, H. T. Ho, JA. Tardy, Y. Guillaneuf, S. Pascual, L. Fontaine, J. Nicolas, Macromolecules 2015, 48(7), 2087-2097
• T. Ho, J. Coupris, S. Pascual, L. Fontaine, T. Lequeux, T. N. Pham, Polym. Chem. 2015, 6, 4597-4604
• Leroux, V. Montembault, S. Piogé, S. Pascual, G. Brotons, L. Fontaine, Macromolecules 2016, 49, 4739-4745
• Leroux, V. Montembault, S. Piogé, S. Pascual, L. Fontaine, Polym. Bull. 2017, 74, 4415-4422
• Pray-In, C. Boonthip, B. Rutnakornpituk, U. Wichai, V. Montembault, S. Pascual, L. Fontaine, M. Rutnakornpituk, Materials Science & Engineering, C: Materials for Biological Applications 2016, 67, 285-293
• M. Le Bohec, M. Banère, S. Piogé, S. Pascual, L. Benyahia, L. Fontaine, Polym. Chem. 2016, 7, 6834
• T. Ho, M. Le Bohec, J. Frémaux, S. Piogé, N. Casse, L. Fontaine, S. Pascual, Macromol. Rapid Commun. 2017, 38, Article Number 1600641
• T. Ho, A. Bénard, G. Forcher, M. Le Bohec, V. Montembault, S. Pascual, L. Fontaine, Org. Biomol. Chem. 2018, 16, 7124-7128.