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Domino Sequences

Domino Sequences

The access a wide variety of original stereocontrolled N-heterocycles in one step starting from similar substrates employing a tunable and atom economic domino process is the goal of this project. The modularity of the domino process based both on the functionalization of the substrates and the experimental conditions employed allow the access to a variety of polycyclic systems from commercially available compounds. This project is supported by the anticipation of the outcome involved via a rational approach based on DFT calculations.



  • Arnaud Martel
  • Mathieu Laurent

Related papers

  • Le Goff, R.; Martel, A.; Sanselme, M.; Lawson, A. M.; Daïch, A.; Comesse, S. Chem. - Eur. J. 2015, 21 (7), 2966.
  • El Bouakher, R. Le Goff, J. Tasserie, J. Lhoste, A. Martel, S. Comesse, Org. Lett. 2016, 18, 2383-2386.
  • El Bouakher, A.; Tasserie, J.; Le Goff, R.; Lhoste, J.; Martel, A.; Comesse, S. J. Org. Chem. 2017, 82 (11), 5798.
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